Function
|
Genes
|
References (examples)
|
Apoptosis | Death associated protein kinase (DAP kinase, 9q34), |
254–257 |
Caspase 8 (CASP8, 2q33-34), |
258 |
Target of methylation induced silencing (TMS1, 16p11.2-12.1) |
183, 259
|
Angiogenesis | Thrombospondin-1 (THBS1, 15q15) |
260 |
Cell cycle | Retinoblastoma (RB, 13q14) |
261–264 |
p14ARF (9p21) |
265–267 |
Cyclin dependent kinase 2A (CDKN2A, 9p21) |
268–272 |
Cyclin dependent kinase 2B (CDKN2B, 9p21), |
243,273–275 |
p27/KIP1 (12p13), |
276
|
p73 (TP73, 1p36) |
277 |
14-3-3ς (stratifin, SFN, 1p) |
185, 187, 188
|
Differentiation | Myogenic differentiation antigen-1 (MYOD, 11p15.4) |
278 |
Paired box gene 6 (PAX6, 11p13) |
279 |
Retinoic acid receptor (RARβ2, 3p24) |
280–284
|
Wilms tumour 1 (WT1, 11p13) |
285
|
DNA repair |
hMLH1(3p23-p21.3) |
91,186,189–191, 194, 195 |
O-6-methylguanine-DNA methyltransferase (MGMT, 10q26) |
286–292
|
Metastasis/invasion | E-cadherin (CDH1, 16q22.1) |
219, 293–298 |
Tissue inhibitor of metalloproteinase 3 (TIMP-3) |
299 |
Maspin (protease inhibitor 5, PI5, 18q21.3) |
300
|
Drug resistance/ detoxification | Glutathione S-transferase π (GSTP1,11q13) |
301, 302 |
Multi-drug resistance 1 (MDR1, 7q21.1) |
303
|
Signal transduction | Adenomatous polyposis of the colon (APC, 5q21-22) |
304
|
PTEN (10q23.3) |
305, 306 |
Androgen receptor (AR, Xq11-12) |
307 |
Oestrogen receptor 1 (ESR1, 6q25.1) |
308–310
|
Ras association domain family member 1 (RASSF1A, 3p21.3) |
204
|
Serine/threonine protein kinase 11 (STK11 orLKB1,19p13.3) |
311 |
Transcription/ transcription factors | Von Hippel-Lindau syndrome (VHL, 3p26-p25) |
176, 312
|
Hypermethylated in cancer (HIC-1, 17p13.3) |
313, 314 |
Breast cancer, type 1 (BRCA1, 17q21) |
177, 315–317
|
Other | CD44 antigen (CD44, 11pter-p13) |
318 |
Cyclo-oxygenase 2 (COX2, 1q25.2-25.3) |
319 |
Calcium channel, voltage dependent, T type, alpha-1G subunit (CACNA1G, 17q22) |
320 |
Calcitonin (CALCA, 11p15.2-15.1) |
321–325
|
Fragile histidine triad gene (FHIT, 3p14.2) |
326 |
Telomerase reverse transcriptase (TERT, 5p15.33) |
327, 328
|
Transmembrane protein containing epidermal growth factor and follistatin domains (TPEF, 2q33) |
329
|
Chondroitin sulphate proteoglycan 2 (CSPG2, 5q12-14) |
330
|