Dosage quotients (DQ) and standard deviation (SD) calculations for electrophoretograms shown in fig1
Exon | Sample peak height | Control peak height | DQs ex1 | DQs ex2 | DQs ex3 |
Sample A Deleted for exons and 8 and 15A, 15D, and 15F | |||||
APC8 | 270 | 494 | 0.50 | 0.51 | 0.48 |
APC15A | 217 | 359 | 0.55 | 0.56 | 0.53 |
APC15D | 219 | 415 | 0.48 | 0.49 | 0.46 |
APC15F | 234 | 452 | 0.47 | 0.48 | 0.45 |
PO1 | 340 | 309 | |||
PO2 | 342 | 319 | |||
PO3 | 353 | 307 | |||
Mean DQ (exons 8 and 15) | |||||
0.50 | |||||
SD | |||||
0.035 | |||||
Sample B Deleted for exons 15A, 15D, and 15F | |||||
APC8 | 916 | 494 | 0.85 | 0.98 | 0.90 |
APC15A | 414 | 359 | 0.53 | 0.61 | 0.56 |
APC15D | 402 | 415 | 0.44 | 0.51 | 0.47 |
APC15F | 465 | 452 | 0.47 | 0.54 | 0.50 |
PO1 | 675 | 309 | |||
PO2 | 603 | 319 | |||
PO3 | 634 | 307 | |||
Mean DQ (exon 8) | Mean DQ (exon 15) | ||||
0.91 | 0.51 | ||||
SD | SD | ||||
0.067 | 0.052 | ||||
Sample C Normal | |||||
APC8 | 375 | 494 | 1.00 | 1.15 | 1.10 |
APC15A | 265 | 359 | 0.97 | 1.12 | 1.07 |
APC15D | 249 | 415 | 0.79 | 0.91 | 0.87 |
APC15F | 308 | 452 | 0.90 | 1.04 | 0.99 |
PO1 | 234 | 309 | |||
PO2 | 210 | 319 | |||
PO3 | 211 | 307 | |||
Mean DQ (exons 8 and 15) | |||||
0.99 | |||||
SD | |||||
0.110 |