Table 1

Clinical manifestations in patients with Wolfram syndrome

Family and patient Age1-150 Gender Diabetes mellitus Progressive optic atrophy Abnormal audiogram Diabetes insipidus Renal tract abnormalities Other complications (age at onset)
1.129 yF7 y11 y11 y20 y20 yHypogonadism
1.220 yM6 y7 yNDSeizures (19 y)
2.122 yF8 y16 yCataract (2 y)
  • 1-150 Age at time of the study.

  • ND, not determined.