Table 1

Results of FISH on patient using 28 clones from 6p21.2-6p25.3 and 18 clones from 22q11.2-q13.32. All clones produced hybridisation signals on the normal chromosomes. Markers contained within each particular chromosome 6 clone are shown as landmarks for mapping and orientation purposes.The physical distances from the centromere of the chromosome 22 probes are taken from the Sanger Centre data (see materials and methods). The probes in both sections are ordered from 22q telomere (top) to centromere (bottom)

Chromosome location	Probe	This case 6p (der)	Distance (22cen) markers (6p)
22q13.31-13.32	bk722'e9	+	33.3Mb
22q (NV)	dJ127b20	+	29 Mb
22q13.1-13.2	bk397c4	+	28.3 Mb
22q13.2	dJ186O1	+	25.9 Mb
22q13.1	bk229a8	+	24.46Mb
22q (NV)	dJ124O7	−	21.8 Mb
22q12.3-q13.1	bk390b3	−	21.3 Mb
22q12.3	bk212a12	−	19.98 Mb
22q (NV)	dJ78b3	−	19.9 Mb
22q (NV)	dJ153h10	−	19.2 Mb
22q (NV)	dJ288l1	−	18.7 Mb
22q12.1-12.2	dJ213F7	+	16.2 Mb
22q12.1	bk99f11	−	15.2 Mb
22q (NV)	dJ90l6	−	11.2 Mb
22q11.23-q12.1	bk992d9	−	11 Mb
22q11.2	bk433f6	−	4.4 Mb
22q11.2	bk154h4	−	3.2 Mb
22q11.2	bk115f6	−	1.7 Mb
6p25.3	c6k23	+
6p25	947d4	+	D6S344
6p25	954h10	+	GMDS
6p25	dJ36i2	+	A339YD9
6p25	878b10	+	D6S477
6p25px	863b6	+	F13A
6p25px	938b10	+	PREB1
6p25px	786h6	+	D6S1640
6p25px	963h4	+	BMP6
6p24.3	848c12	+	D6S410
6p24.3	808a10	+
6p24.3	dJ103m22	+
6p24.3	bk3J9	+	stSG11165
6p24.3	dJ359l13	+
6p24.3	dJ108c15	+	stSG11171
6p24.3	dJ167k8	+	stSG11171
6p24.3	dJ110p13	+	stSG11216
6p24.3	dJ135k15	+	stSG11216
6p24.3	dJ133h11	+
6p24.3	886c1	+	AP-2
6p24.3	753a9	+
6p24.3	436h5	+
6p24.2	938d8	+	AP-2
6p24.1	915e'8	+	GCNT2
6p24.1px	844h3	+	ZNF40
6p24.1px	886a2	+	D6S429
6p23	912g9	+
6p21.2	bk121l5	+

+ = presence and− = absence of a hybridisation signal on the der (6).
c = cosmids, dJ = PACS, bk = BACS, those without a prefix are YAC clones, NV = not verified.