Table 1

Spontaneous and mitomycin C (MMC) induced chromosomal aberrations in the index patient, a NBS patient, and a control. The cells were cultured for the last 24 hours before harvesting in medium containing the bifunctional alkylating agent MMC

MMC ng/ml % aberrant metaphases Breaks/cell
Control080.08
50100.12
10080.12
NBS080.12
50140.18
100260.34
Patient040.06
50300.46
100280.43