Frequency of disease manifestations in AFD carriers >18 years
| Disease manifestation | Present in % patients | Number of patients investigated |
| Neuropathic pain | 70 | 60 |
| Angiokeratoma | 35 | 60 |
| Hypohidrosis | 32.8 | 60 |
| TIA or CVA | 21.5 | 60 |
| End stage renal failure | 3.3 | 60 |
| Abnormal renal function | 35 | 20 |
| Chest pain/palpitation | 52.5 | 60 |
| Left ventricular hypertrophy | 19 | 21 |
| Heart valve abnormalities | 47.6 | 21 |
| Arrythmia | 33 | 21 |
| Lymphoedema | 8.3 | 60 |
| GI symptoms | 58.3 | 60 |
| Fatigue | 66 | 60 |
| Self reported hearing loss | 23.3 | 60 |
| Tinnitus | 25 | 60 |
The cohort examined in this study consisted of 60 obligate carrier females, mean age 44.9 years (95% CI 41.01, 48.79). Data on disease manifestations obtained from the questionnaire were complete; however, as only one-third of these women were investigated, the frequencies of cardiac and renal abnormalities should be regarded as approximate.