Onset of disease manifestations in AFD males
| Disease manifestation |
Mean age of onset (95% CI) | Total number of patients investigated |
| Neuropathic pain | 10.1 (8.6, 11.6) | 93 |
| Angiokeratoma | 16.8 (14, 19.6) | 73 |
| CVA (excluded are children <18 years) | 40.4 (35.5, 45.2) | 70 |
| TIA (excluded are children <18 years) | 38.8 (35.2, 42.9) | 70 |
| Renal dialysis | 36.7 (32.6, 40.7) | 84 |
| Renal transplant | 40 (34.5, 45.5) | 84 |
| Left ventricular hypertrophy | 42 (37.9, 45) | 34 |
| Self reported hearing loss | 29 (26.6, 31.4) | 61 |
Data on the onset of characteristic and serious disease manifestations were obtained from patients attending the clinic and from those evaluated by their own physicians. The variable numbers of patients in several groups represent those that were investigated.