Sensitivity and specificity of clinical criteria for identifying kindreds with pathogenic hMSH2 or MLH1 mutations
| No of families with mutations in MSH2 or MLH1 | % Families fulfilling criteria (n=70) | % Families with mutations missed by criteria (n=18) | Sensitivity of criteria (95% CI) | Specificity of criteria (95% CI) | |
| Amsterdam | 11 | 40 (28) | 39 (7) | 61% (43%, 79%) | 67% (50%, 85%) |
| Modified Amsterdam | 13 | 56 (39) | 28 (5) | 72% (58%, 86%) | 50% (34%, 66%) |
| Amsterdam II | 14 | 49 (34) | 22 (4) | 78% (64%, 92%) | 61% (45%, 78%) |
| Bethesda | 17 | 80 (56) | 6 (1) | 94% (88%, 100%) | 25% (14%, 36%) |
| Bethesda (1–3) | 17 | 63 (44) | 6 (1) | 94% (88%, 100%) | 49% (34%, 64%) |