Clinical criteria for HNPCC
| Name | Criteria | ||
| Amsterdam1-150 18 | Three relatives with colorectal cancer (CRC), one of whom is a first degree relative of the other two; CRC involving at least two generations; one or more CRC cases diagnosed before the age of 50 | ||
| Modified Amsterdam1-151 20 24 | (1) | Very small families, which cannot be further expanded, can be considered as HNPCC even if only two CRCs in first degree relatives; CRC must involve at least two generations, and one or more CRC cases must be diagnosed under age 55. | |
| or | |||
| (2) | In families with two first degree relatives affected by colorectal cancer, the presence of a third relative with an unusual early onset neoplasm or endometrial cancer is sufficient. | ||
| Amsterdam II21 | Three relatives with an HNPCC associated tumour (CRC, endometrial, small bowel, ureter, or renal pelvis), one of whom is a first degree relative of the other two; involving at least two generations; one or more cases diagnosed before the age of 50 | ||
| Bethesda1-151 19 | (1) | Subjects with cancer in families that fulfil Amsterdam criteria | |
| (2) | Subjects with two HNPCC related cancers, including synchronous and metachronous CRCs or associated extracolonic cancers | ||
| (3) | Subjects with CRC and a first degree relative with colorectal cancer and/or HNPCC related extracolonic cancer and/or colorectal adenoma; one of the cancers diagnosed at age <45 years and the adenoma diagnosed at age <40 years | ||
| (4) | Subjects with CRC or endometrial cancer diagnosed at age <45 years | ||
| (5) | Subjects with right sided CRC with an undifferentiated pattern (solid/cribiform) on histopathology diagnosed at age <45 years | ||
| (6) | Subjects with signet ring cell type CRC diagnosed at age <45 years | ||
| (7) | Subjects with adenomas diagnosed at age <40 years | ||