Table 1

Calculations using the algorithms of Wijnen et al¹ to determine the probabilities of finding a germline MLH1 or MSH2 mutation in 28 mutation carrier probands

Patient	Mean age of diagnosis of CRC in the family	Fulfilment of Amsterdam criteria	Endometrial cancer in the family	No of patients with CRC	No of patients with endometrial cancer	No of family members with verified cancer status	p₁	p₂
(A) Limited pedigrees (proband and first degree relatives)
c35	49	No	No	2	0	6	3	11
c54	36	No	No	1	0	4	10	24
c64	53	No	No	2	0	5	2	8
c125	52	No	No	2	0	9	2	9
c145	42	Yes	Yes	3	1	12	78	40
c219	50	No	Yes	1	1	7	13	16
c340	61	No	Yes	3	2	7	5	20
c430	38	No	No	2	0	4	8	25
c558	57	No	Yes	4	2	8	7	32
c564	45	No	Yes	2	1	7	19	28
c138	39	No	No	1	0	5	8	19
c275	55	No	No	2	0	9	2	7
c587	36	No	Yes	2	1	4	37	46
c614	50	No	Yes	3	2	6	13	40
c615	38	No	No	2	0	5	8	25
c661	54	No	Yes	1	1	6	9	12
c676	46	No	Yes	2	1	7	18	26
c698	43	No	Yes	1	1	6	22	26
c700	61	No	No	1	0	5	1	3
c811	54	No	No	2	0	14	2	7
c870	56	No	No	2	0	5	1	6
c899	50	No	No	2	0	6	3	10
c952	52	No	Yes	2	1	10	11	17
c953	45	No	Yes	6	3	9	19	83
c955	53	No	No	2	0	7	2	8
c1027	53	No	No	1	0	8	2	6
c1077	45	Yes	No	3	0	8	34	19
c1095	53	Yes	Yes	3	1	8	55	20

(B) Extended pedigrees
c35	47	Yes	No	4	0	24	30	21
c54	35	No	No	1	0	13	11	25
c64	53	Yes	No	4	0	24	10	16
c125	48	Yes	No	4	0	14	28	19
c145	56	Yes	Yes	13	3	85	48	93
c219	52	No	Yes	7	2	49	11	62
c340	56	Yes	Yes	5	2	33	48	40
c430	44	Yes	Yes	9	1	33	75	73
c558	57	Yes	Yes	5	3	39	45	57
c564	45	Yes	Yes	12	4	77	73	98
c138	38	No	Yes	1	1	8	32	35
c275	46	Yes	Yes	10	4	87	71	97
c587	42	No	Yes	3	1	14	24	40
c614	49	No	Yes	3	2	42	14	42
c615	40	Yes	No	3	0	16	46	27
c661	54	No	Yes	1	1	24	9	12
c676	44	Yes	Yes	12	4	74	75	98
c698	46	Yes	Yes	10	4	87	71	97
c700	49	No	Yes	13	5	97	14	99
c811	48	Yes	No	5	0	29	28	24
c870	56	No	No	2	0	20	1	6
c899	50	No	No	2	0	8	3	10
c952	64	No	Yes	3	1	11	3	8
c953	44	Yes	Yes	12	4	74	75	98
c955	47	No	No	3	0	25	4	17
c1027	43	No	Yes	2	1	20	22	31
c1077	44	Yes	No	7	0	46	37	43
c1095	53	Yes	Yes	3	1	12	55	20

p₁ = probability of finding a germline mutation inMLH1 or MSH2.
p₂ = probability of finding a germline mutation inMLH1 or MSH2; the alternative formula.