Table 2

Extent and origin of the 4p deletion in patients 1–6

Distance from 4pter Microsatellite marker Cosmid YAC Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6
∼ 200 kbpC847.351 (D4F26)deldeldeldeldeldel
∼ 1.2 MbpC678 (D4S96)deldeldeldeldeldel
∼ 1.9 MbL75B9 RepMMM
∼ 2.0 MbD4S1182NIMNI
∼ 2.2 MbD4S4333c6 (D4S43)MNINIM
∼ 3.0 MbHu4/Hu5MMNINI
∼ 3.3 MbL21f12 (D4S180)deldeldel
∼ 3.8 MbADRA2CNIMM
∼ 3.8 MbL228a7 (D4S81)deldeldeldeldeldel
∼ 5.5 MbHox7NDNDNINI
∼ 7.0 Mb877G6delND
∼ 8.8 MbD4S2366NDNDM
∼ 13.0 Mb405D10deldeldelND
∼ 14.0 Mb794D12NDNDNDND
∼ 16.5 MbD4S403NDNDND
∼ 19.8 Mb225D2NDNDNDND
∼ 21.5 Mb435A11NDND
∼ 23.0 MbD4S2639NDNDNDND
∼ 34.0 MbD4S2397NDNDNDND
  • del: deleted; ND: not deleted; NI: not informative; M: maternally deleted.