Heterozygous and homozygous MTHFR C677T genotype frequencies in published NTD cases
| No of NTD cases | No heterozygous (%) | No homozygous (%) | Homozygous odds ratio | 95% confidence interval | Reference |
|---|---|---|---|---|---|
| 214 | 100 (47) | 41 (19) | Not reported | — | 12 |
| 153 | Not reported | 29 (19) | 2.6 | 1.4–4.8 | 16 |
| 137 | 60 (44) | 19 (14) | Not reported | — | 19 |
| 82 | 32(39) | 15 (18) | 3.5 | 1.3–9.4 | 14 |
| 56 | 26 (46) | 11(20) | 2.2 | 0.8–6.0 | 26 |
| 55 | 26 (47) | 7(13) | 2.9 | 1.0–7.9 | 15 |
| 82 | 30 (37) | 9(11) | 6.6 | 1.3–24.9 | Our study |