Odds ratios and 95% confidence intervals of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) genotypes in fetuses with NTDs (cases) and controls
| Genotype | NTDs (cases) | Controls | Odds ratio | 95% confidence interval |
|---|---|---|---|---|
| MTHFR | ||||
| Ala/Ala | 43/82 (52%) | 63/76 (83%) | 1.0 | |
| Ala/Val | 30/82 (37%) | 11/76 (14%) | 4.0 | 1.8–8.8 |
| Val/Val | 9/82 (11%) | 2/76 (3%) | 6.6 | 1.3–24.9 |
| MS | ||||
| Asp/Asp | 59/77 (77%) | 70/84 (83%) | 1.0 | |
| Asp/Gly | 18/77 (23%) | 13/84 (14%) | 1.6 | 0.7–3.6 |
| Gly/Gly | 0/77 (0%) | 1/84 (1%) | — | — |