Table 3

Genotypes for the TNFα promoter variants at –238 and –308 in bone sarcoma patients and in healthy controls

Genotype		Controls (n=111)^3-150				Osteosarcoma (n=63)				ES^3-151(n=47)
Genotype		No	%			No	%			No	%
Locus TNFα -308 ^3-152
GG	83	74.8		49	77.8		41	87.2
GA	28	25.2		14^3-153	22.2		6	12.8
				p=0.65, NS, OR=0.85 (CI 0.41, 1.76)			p=0.08, NS, OR=0.43 (CI 0.17, 1.13)
Locus TNFα -238
GG	93	83.8		61	96.8		41	87.2
GA	18	16.2		2	3.2		6	12.8
				p=0.0095, ^3-154, OR=0.17 (CI 0.04, 0.76)			p=0.58, NS, OR=0.76 (CI 0.28, 2.04)

↵3-150 Number of subjects analysed.
↵3-151 ES, Ewing's sarcoma.
↵3-152 In each polymorphism G is the normal allele and A is the polymorphic one.
↵3-153 13 patients are GA and one is AA.
↵3-154 Statistically significant.