Frequencies of the TNFα promoter alleles –238 and –308 in the paediatric bone sarcoma groups compared to control children
| Allele | Controls (n=222)2-150 | Osteosarcoma (n=126) | ES2-151(n=94) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No | % | No | % | No | % | ||||||
| Locus TNFα -308 | |||||||||||
| G (TNF308.1) | 194 | 87.4 | 111 | 88.1 | 88 | 93.6 | |||||
| A (TNF308.2) | 28 | 12.6 | 15 | 11.9 | 6 | 6.4 | |||||
| p=0.847, NS, OR=0.94 (CI 0.48, 1.83) | p=0.102, NS, OR=0.47 (CI 0.19, 1.18) | ||||||||||
| Locus TNFα -238 | |||||||||||
| G (TNF238.1) | 204 | 91.9 | 124 | 98.4 | 88 | 93.6 | |||||
| A (TNF238.2) | 18 | 8.1 | 2 | 1.6 | 6 | 6.4 | |||||
| p=0.012, 2-152, OR=0.18 (CI 0.042, 0.8) | p=0.6, NS, OR=0.77 (CI 0.29, 2.01) | ||||||||||