Table 2

Risk of AD and PD for carriers of APOE ε4, DCP1 *I, or DCP1 *D, or both alleles (ε4 in combination with DCP1 *I or DCP1 *D), using subjects having neither ε4 nor DCP1*I or DCP1 *D as reference

ADPDPD (B+C)
OR (95% CI)p valueOR (95% CI)p valueOR (95% CI)p value
ε4+/DCP1 *I+30.0  (7.3–123.7)<0.00014.0  (1.3–12.4)0.0168.0  (2.1–31.1)0.003
ε4+/DCP1 *I−9.0 (2.0–40.9)0.0041.3 (0.3–4.9)0.7501.1 (0.2–7.5)0.903
ε4−/DCP1 *I+3.8 (1.0–14.4)0.0541.3 (0.5–3.5)0.5831.7 (0.5–6.0)0.420
ε4−/DCP1 *I−RefRefRef
ε4+/DCP1 *D+6.3 (1.7–23.4)0.0061.6 (0.5–5.5)0.4612.3 (0.5–10.1)0.291
ε4+/DCP1 *D−27.0 (2.6–284.7)0.0069.0 (0.9–94.9)0.06818.0 (1.5–216.6)0.023
ε4−/DCP1 *D+1.0 (0.3–3.8)0.9500.9 (0.3–2.8)0.8241.0 (0.2–4.0)0.946
ε4−/DCP1 *D−RefRefRef
  • OR, odds ratio; CI, confidence interval.