Na+ channel genes associated with neurological and cardiac disorders in human and mouse
| Na+ channel gene | Human disease | Mouse model | Common mutations |
| SCN4A | Hyperkalaemic periodic paralysis | T698M; T704M; M1595V; M1592V; V783I; M1360V | |
| SCN4A | Myotonia fluctuans | G1306A | |
| SCN4A | Myotonia permanens | G1306E | |
| SCN4A | Myotonia acetazolamide responsive | I1160V | |
| SCN4A | Paramyotonia congenita | I693T; V1293I; G1306V; T1313M; L1433R; R1448C; R1448H, R1448P; R1448S; V1458F; F1473S; V1589M | |
| SCN5A | Long QT syndrome type 3 | Deletion KPQ 1505-1507; N1325S; R1644H; R1623Q | |
| Scn8a | Motor end plate disease | Transgene induced intragenic deletion | |
| Scn8a | Jolting | A1071T |