K+ channel genes associated with neurological and cardiac disorders in human and mouse
| K+ channel gene | Human disease | Mouse model | Common mutations |
| KCNA1 | Episodic ataxia type 1 | V408A; R239S; V174F; F249I; F184C; E325D; T226A; V404I; I176R | |
| KCNE1 | Long QT syndrome type 1 | S74L, D76N | |
| KCNQ1 | Long QT syndrome type 1 | 3 nucleotides deletion (TCG in codon 72); A83P; G189R; R95Q; V159M; L178F; G211R; T217I; A341E; A341V; G250E; G219S; R555C; W305S; A300T; R518T; A529T; 3 bp deletion (F339); 9 bp deletion del373-381 | |
| HERG | Long QT syndrome type 2 | 1 bp deletion (1261); 27 bp deletion (1500); A561V; N470D; I593R; V822M; G628S; R582C | |
| KCNJ6(GIRK2) | Weaver | G156S | |
| KCNQ2 | Benign familial neonatal convulsions | Y284C, A306T; 2 bp insertion (283 ins GT); 13 bp deletion at amino acid 522; 1 bp deletion, del2513G | |
| KCNQ3 | Benign familial neonatal convulsions | G263V |