Table 1

Two point lod scores of chromosome 1q41 markers versus the USH2A gene in (A) family 1 and (B) family 2. Usher syndrome was assumed to be inherited as a fully penetrant autosomal recessive disorder with a gene frequency of 4.4:100 000 in family 1 and 3.0:100 000 in family 2. There was no significant effect on the lod scores using allele frequencies calculated from 25 normal subjects in each population compared with assuming equal marker allele frequencies

MarkerRecombination fractionθZmax
0.000.010.050.10.20.30.4
A
D1S4252.952.892.572.191.440.770.230.02.95
D1S505−∞0.180.850.990.810.470.140.10.99
D1S2172.232.181.961.701.190.700.240.02.23
D1S27032.922.852.542.161.420.750.220.02.92
D1S2372.242.191.971.711.190.690.230.02.24
D1S26293.093.022.712.341.600.890.290.03.09
D1S26462.942.862.562.171.430.760.220.02.94
D1S28270.780.750.650.530.300.140.040.00.78
D1S229−0.30−0.23−0.060.030.060.030.010.20.06
D1S490−0.32−0.24−0.070.010.050.030.000.20.05
B
D1S4252.732.672.422.111.500.920.420.02.73
D1S5057.657.486.835.994.282.550.990.07.65
D1S2177.217.066.425.634.002.380.900.07.21
D1S27037.537.376.725.894.202.510.960.07.53
D1S2374.204.113.753.292.331.400.570.04.20
D1S26297.066.916.315.563.982.380.910.07.06
D1S26466.956.806.195.423.862.310.890.06.95
D1S28277.217.066.435.634.002.380.900.07.21
D1S2296.836.696.105.373.852.300.880.06.83
D1S4907.066.916.315.553.982.380.910.07.06