Table 1

RET polymorphic alleles in HSCR and normal controls

HSCR allelesControl alleles
(A) Over-representation of the A45A polymorphic allele in HSCR versus controls
Polymorphic A7532
 Wild type G53168
Chi-squared, Yates’s correction = 62.50, p<<0.0001
(B) Over-representation of the L769L polymorphic allele in HSCR versus controls
Polymorphic C3928
 Wild type G89172
Chi-squared, Yates’s correction = 12.03, p=0.0005
(C) Under-representation of the G691S or S904S polymorphic allele in HSCR versus controls
Polymorphic allele1647
 Wild type allele112153
Chi-squared, Yates’s correction = 5.40, p=0.02
(D) Polymorphisms with similar frequencies in HSCR and controls
V125V (exon 3), p=0.15
Polymorphic allele96
 Wild type allele119194
A432A (exon 7), p=0.14
Polymorphic allele2860
 Wild type allele100140
S836S (exon 15), p=0.54
Polymorphic allele38
 Wild type allele125192