Distribution of the identified BRCA gene mutations according to the average age at diagnosis of breast cancer and of ovarian cancer
| No of families | No of mutations BRCA1 or 2 | % of families mutation found | |
|---|---|---|---|
| Average age at diagnosis of breast cancer among family members (y)3-150 | |||
| <35 | 2 | 1 | 50 |
| 35–39 | 2 | 1 | 50 |
| 40–44 | 8 | 5 | 63 |
| 45–49 | 13 | 4 | 31 |
| 50–54 | 10 | 2 | 20 |
| 55–59 | 1 | 0 | 0 |
| >59 | 3 | 0 | 0 |
| Total | 39 | 13 | 33 |
| Average age at diagnosis of ovarian cancer among family members (y)3-151 | |||
| <45 | 2 | 2 | 100 |
| 45–49 | 3 | 3 | 100 |
| 50–54 | 2 | 0 | 0 |
| 55–59 | 5 | 3 | 60 |
| >59 | 1 | 0 | 0 |
| Total | 13 | 8 | 62 |
↵3-150 The median of the average ages at diagnosis of breast cancer was 44 years in the families with a BRCA mutation versus 47.5 years in the families without an identified mutation (p=0.015).
↵3-151 The median of the average ages at diagnosis of ovarian cancer was 47.6 years in the first group of families and 56 years in the families where no mutation was found (p=0.093).