RT Journal Article SR Electronic T1 Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 220 OP 229 DO 10.1136/jmedgenet-2020-107416 VO 59 IS 3 A1 Yoon, Sook-Yee A1 Wong, Siu Wan A1 Lim, Joanna A1 Ahmad, Syuhada A1 Mariapun, Shivaani A1 Padmanabhan, Heamanthaa A1 Hassan, Nur Tiara A1 Lau, Shao Yan A1 Ch'ng, Gaik-Siew A1 Haniffa, Muzhirah A1 Ong, Winnie P A1 Rethanavelu, Kavitha A1 Moey, Lip Hen A1 Keng, Wee Teik A1 Omar, Jamil A1 Mohd Abas, Mohd Norazam A1 Yong, Chee Meng A1 Ramasamy, Vickneswaren A1 Md Noor, Mohd Rushdan A1 Aliyas, Ismail A1 Lim, Michael C K A1 Suberamaniam, Anuradha A1 Mat Adenan, Noor Azmi A1 Ahmad, Zatul Akmar A1 Ho, Gwo Fuang A1 Abdul Malik, Rozita A1 Subramaniam, Suguna A1 Khoo, Boom Ping A1 Raja, Arivendran A1 Chin, Yeung Sing A1 Sim, Wee Wee A1 Teh, Beng Hock A1 Kho, Swee Kiong A1 Ong, Eunice S E A1 Voon, Pei Jye A1 Ismail, Ghazali A1 Lee, Chui Ling A1 Abdullah, Badrul Zaman A1 Loo, Kwong Sheng A1 Lim, Chun Sen A1 Lee, Saw Joo A1 Lim, Keng Joo Lim A1 Shafiee, Mohamad Nasir A1 Ismail, Fuad A1 Latiff, Zarina Abdul A1 Ismail, Mohd Pazudin A1 Mohamed Jamli, Mohamad Faiz A1 Kumarasamy, Suresh A1 Leong, Kin Wah A1 Low, John A1 Md Yusof, Mastura A1 Ahmad Mustafa, Ahmad Muzamir A1 Mat Ali, Nor Huda A1 Makanjang, Mary A1 Tayib, Shahila A1 Cheah, Nellie A1 Lim, Boon Kiong A1 Fong, Chee Kin A1 Foo, Yoke Ching A1 Mellor Abdullah, Matin A1 Tan, Teck Sin A1 Chow, Doris S Y A1 Ho, Kean Fatt A1 Raman, Rakesh A1 Radzi, Ahmad A1 Deniel, Azura A1 Teoh, Daren C Y A1 Ang, Soo Fan A1 Joseph, Joseph K A1 Ng, Paul Hock Oon A1 Tho, Lye-Mun A1 Ahmad, Azura Rozila A1 Muin, Ileena A1 Bleiker, Eveline A1 George, Angela A1 Thong, Meow-Keong A1 Woo, Yin Ling A1 Teo, Soo Hwang YR 2022 UL http://jmg.bmj.com/content/59/3/220.abstract AB Background Identifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming.Methods The Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer.Results Oncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms.Conclusion The MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.Data are available on reasonable request. The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.