PT - JOURNAL ARTICLE AU - Yoon, Sook-Yee AU - Wong, Siu Wan AU - Lim, Joanna AU - Ahmad, Syuhada AU - Mariapun, Shivaani AU - Padmanabhan, Heamanthaa AU - Hassan, Nur Tiara AU - Lau, Shao Yan AU - Ch'ng, Gaik-Siew AU - Haniffa, Muzhirah AU - Ong, Winnie P AU - Rethanavelu, Kavitha AU - Moey, Lip Hen AU - Keng, Wee Teik AU - Omar, Jamil AU - Mohd Abas, Mohd Norazam AU - Yong, Chee Meng AU - Ramasamy, Vickneswaren AU - Md Noor, Mohd Rushdan AU - Aliyas, Ismail AU - Lim, Michael C K AU - Suberamaniam, Anuradha AU - Mat Adenan, Noor Azmi AU - Ahmad, Zatul Akmar AU - Ho, Gwo Fuang AU - Abdul Malik, Rozita AU - Subramaniam, Suguna AU - Khoo, Boom Ping AU - Raja, Arivendran AU - Chin, Yeung Sing AU - Sim, Wee Wee AU - Teh, Beng Hock AU - Kho, Swee Kiong AU - Ong, Eunice S E AU - Voon, Pei Jye AU - Ismail, Ghazali AU - Lee, Chui Ling AU - Abdullah, Badrul Zaman AU - Loo, Kwong Sheng AU - Lim, Chun Sen AU - Lee, Saw Joo AU - Lim, Keng Joo Lim AU - Shafiee, Mohamad Nasir AU - Ismail, Fuad AU - Latiff, Zarina Abdul AU - Ismail, Mohd Pazudin AU - Mohamed Jamli, Mohamad Faiz AU - Kumarasamy, Suresh AU - Leong, Kin Wah AU - Low, John AU - Md Yusof, Mastura AU - Ahmad Mustafa, Ahmad Muzamir AU - Mat Ali, Nor Huda AU - Makanjang, Mary AU - Tayib, Shahila AU - Cheah, Nellie AU - Lim, Boon Kiong AU - Fong, Chee Kin AU - Foo, Yoke Ching AU - Mellor Abdullah, Matin AU - Tan, Teck Sin AU - Chow, Doris S Y AU - Ho, Kean Fatt AU - Raman, Rakesh AU - Radzi, Ahmad AU - Deniel, Azura AU - Teoh, Daren C Y AU - Ang, Soo Fan AU - Joseph, Joseph K AU - Ng, Paul Hock Oon AU - Tho, Lye-Mun AU - Ahmad, Azura Rozila AU - Muin, Ileena AU - Bleiker, Eveline AU - George, Angela AU - Thong, Meow-Keong AU - Woo, Yin Ling AU - Teo, Soo Hwang TI - Oncologist-led <em>BRCA</em> counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes AID - 10.1136/jmedgenet-2020-107416 DP - 2022 Mar 01 TA - Journal of Medical Genetics PG - 220--229 VI - 59 IP - 3 4099 - http://jmg.bmj.com/content/59/3/220.short 4100 - http://jmg.bmj.com/content/59/3/220.full SO - J Med Genet2022 Mar 01; 59 AB - Background Identifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming.Methods The Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer.Results Oncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms.Conclusion The MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.Data are available on reasonable request. The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.