PT - JOURNAL ARTICLE AU - Forde, Claire AU - Brunstrom, Kate AU - Woodward, Emma AU - Bowers, Naomi AU - Pereira, Marta AU - Wallace, Andrew J AU - Lalloo, Fiona AU - Harkness, Elaine F AU - Evans, D Gareth TI - Uptake of pre-symptomatic testing for <em>BRCA1</em> and <em>BRCA2</em> is age, gender, offspring and time-dependent AID - 10.1136/jmedgenet-2019-106544 DP - 2021 Feb 01 TA - Journal of Medical Genetics PG - 74--78 VI - 58 IP - 2 4099 - http://jmg.bmj.com/content/58/2/74.short 4100 - http://jmg.bmj.com/content/58/2/74.full SO - J Med Genet2021 Feb 01; 58 AB - Background Genetic testing for BRCA1 and BRCA2 pathogenic variants (PVs) has been available in North West England since 1995. We assessed uptake of pre-symptomatic testing in 1564 families with PVs over a 24.5year follow-up (FU) period.Methods First-degree relatives (FDRs) in families with BRCA1 or BRCA2 PVs were eligible from date of index family report if unaffected by a relevant cancer and alive at report date. FDRs were censored as not having undergone a pre-symptomatic test at diagnosis of a relevant cancer, date of death, age 93 or 30/03/2019. Time to uptake of pre-symptomatic testing was assessed by Kaplan–Meier curves, by gender and children.Results 2554 male and 3115 female FDRs were eligible. Overall uptake was 775 (30.3%) in men and 1935 (62.1%) in women. This increased at 15 years to 33.6% and 67.9%, and continued to rise until 24 years (p&lt;0.001). For women, the 29-year to 39-year age group had the highest uptake at 10 years FU (72.5%; p&lt;0.01), whereas the 50-year to 59-year age group was highest in men (37.2%; p&lt;0.01). Women &lt;18 years at the time of familial variant identification had lower initial uptake, but this rose to &gt;80% by 15 years. Uptake was higher in parous women (p&lt;0.001) and in men with daughters (p&lt;0.0001).Conclusion Uptake of BRCA1/2 pre-symptomatic testing is age, gender and time-dependent, and higher in women with children and men with daughters.