RT Journal Article SR Electronic T1 UKCGG Consensus Group guidelines for the management of patients with constitutional TP53 pathogenic variants JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP jmedgenet-2020-106876 DO 10.1136/jmedgenet-2020-106876 A1 Helen Hanson A1 Angela F Brady A1 Gillian Crawford A1 Rosalind A Eeles A1 Sarah Gibson A1 Mette Jorgensen A1 Louise Izatt A1 Aslam Sohaib A1 Marc Tischkowitz A1 D Gareth Evans A1 , YR 2020 UL http://jmg.bmj.com/content/early/2020/06/22/jmedgenet-2020-106876.abstract AB Constitutional pathogenic variants in TP53 are associated with Li-Fraumeni syndrome or the more recently described heritable TP53-related cancer syndrome and are associated with increased lifetime risks of a wide spectrum of cancers. Due to the broad tumour spectrum, surveillance for this patient group has been limited. To date, the only recommendation in the UK has been for annual breast MRI in women; however, more recently, a more intensive surveillance protocol including whole-body MRI (WB-MRI) has been recommended by International Expert Groups. To address the gap in surveillance for this patient group in the UK, the UK Cancer Genetics Group facilitated a 1-day consensus meeting to discuss a protocol for the UK. Using a preworkshop survey followed by structured discussion on the day, we achieved consensus for a UK surveillance protocol for TP53 carriers to be adopted by UK Clinical Genetics services. The key recommendations are for annual WB-MRI and dedicated brain MRI from birth, annual breast MRI from 20 years in women and three-four monthly abdominal ultrasound in children along with review in a dedicated clinic.