@article {Garrettjmedgenet-2019-106759, author = {Alice Garrett and Alison Callaway and Miranda Durkie and Cankut Cubuk and Mary Alikian and George J Burghel and Rachel Robinson and Louise Izatt and Sabrina Talukdar and Lucy Side and Treena Cranston and Sheila Palmer-Smith and Diana Baralle and Ian R Berry and James Drummond and Andrew J Wallace and Gail Norbury and Diana M Eccles and Sian Ellard and Fiona Lalloo and D Gareth Evans and Emma Woodward and Marc Tischkowitz and Helen Hanson and Clare Turnbull}, editor = {, and , and Abbs, Stephen and Tarpey, Patrick and Bruty, Jonathan and Drummond, James and Whitworth, James and Bowden, Anne Ramsay and Tischowitz, Marc and Maher, Eamonn and Heggarty, Shirley and Hegarty, Sean and Martin, Rosalind and Logan, Peter and Byrne, Claire and Wallis, Yvonne and Butler, Samantha and Hart, Rachel and Hughes, Lowri and Reay, Kim and Ong, Kai-Ren and Mason, Joanne and Tomlinson, Ian and Frayling, Ian and Palmer-Smith, Sheila and Sampson, Julian and Murray, Alex and Ahmed, Munaza and Kiely, Louise and Busby, Louise and Brooks, Claire and Taylor-Beadling, Alison and Kumar, Ajith and Ryten, Mina and Izatt, Louise and Kulkarni, Anjana and Shaw, Adam and Campbell, Joanna and Thomas, Huw and Chubb, Daniel and Alikian, Mary and Cubuk, Cankut and Robinson, Rachel and Mullaney, Brendan and Adlard, Julian and Greenhalgh, Karen-Lynn and Howard, Emma and Clowes, Virginia and Brady, Angela and Burghel, George and Woodward, Emma and Smith, Philip T and Harris, Jade L and Bowers, Naomi L and Hartley, Claire L and Wright, Ronnie and Evans, Gareth and Lalloo, Fiona and Wallace, Andrew and Burn, John and Tellez, James and Mackenzie, Sarah and Powell, Helen and Tennant, Stephen and Tolmie, Joanna and O{\textquoteright}Sullivan, Dawn and Davidson, Rosemarie and Grant, Jonathan and Stobo, Daniel and Ansari, Aisha and Murray, Jennie and Moore, David and Tredwell, Rachael and Field, Joanne and Bradshaw, Kirsty and Harrison, Rachel and Walker, Logan and Mcdevitt, Trudi and Duff, Marie and Clabby, Catherine and Cranston, Treena and Bedenham, Tina and Petrides, Evgenia and Hawkes, Lara and McRonald, Fiona and Ellard, Sian and Cleaver, Ruth and Brewer, Carole and Woodwaer, Nick and Daniels, Stacey and Callaway, Alison and Tobal, Khalid and Albaba, Shadi and Dell, Sarah and Nyanhete, Rodney and Kirk, Richard and Watson, Mark and Durkie, Miranda and Snape, Katie and Cook, Jackie and Clouston, Hazel and Hogg, Anne-Cecile and Talukdar, Sabrina and Hawkes, Lorraine and Cobbold, Laura and Tatton-Brown, Kate and Hanson, Helen and Crosby, Charlene and Hadonou, Ayaovi and Kemp, Zoe and Mcveigh, Terri and Turnbull, Clare and Garrett, Alice and O{\textquoteright}Brien, Cathal and Yarram, Laura and Smith, Kenneth and Williamson, Helen and Donaldson, Alan and Barwell, Julian and Bradford, Matilda and Side, Lucy and Eccles, Diana and Baralle, Diana and Lucassen, Anneke and Tripathi, Vishakha and Del Rey Jimenez, Juan Carlos}, title = {Cancer Variant Interpretation Group UK (CanVIG-UK): an exemplar national subspecialty multidisciplinary network}, elocation-id = {jmedgenet-2019-106759}, year = {2020}, doi = {10.1136/jmedgenet-2019-106759}, publisher = {BMJ Publishing Group Ltd}, abstract = {Advances in technology have led to a massive expansion in the capacity for genomic analysis, with a commensurate fall in costs. The clinical indications for genomic testing have evolved markedly; the volume of clinical sequencing has increased dramatically; and the range of clinical professionals involved in the process has broadened. There is general acceptance that our early dichotomous paradigms of variants being pathogenic{\textendash}high risk and benign{\textendash}no risk are overly simplistic. There is increasing recognition that the clinical interpretation of genomic data requires significant expertise in disease{\textendash}gene-variant associations specific to each disease area. Inaccurate interpretation can lead to clinical mismanagement, inconsistent information within families and misdirection of resources. It is for this reason that {\textquoteleft}national subspecialist multidisciplinary meetings{\textquoteright} (MDMs) for genomic interpretation have been articulated as key for the new NHS Genomic Medicine Service, of which Cancer Variant Interpretation Group UK (CanVIG-UK) is an early exemplar. CanVIG-UK was established in 2017 and now has \>100 UK members, including at least one clinical diagnostic scientist and one clinical cancer geneticist from each of the 25 regional molecular genetics laboratories of the UK and Ireland. Through CanVIG-UK, we have established national consensus around variant interpretation for cancer susceptibility genes via monthly national teleconferenced MDMs and collaborative data sharing using a secure online portal. We describe here the activities of CanVIG-UK, including exemplar outputs and feedback from the membership.}, issn = {0022-2593}, URL = {https://jmg.bmj.com/content/early/2020/03/13/jmedgenet-2019-106759}, eprint = {https://jmg.bmj.com/content/early/2020/03/13/jmedgenet-2019-106759.full.pdf}, journal = {Journal of Medical Genetics} }