RT Journal Article SR Electronic T1 Clinical features and cancer risk in families with pathogenic CDH1 variants irrespective of clinical criteria JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 838 OP 843 DO 10.1136/jmedgenet-2019-105991 VO 56 IS 12 A1 Rosa M Xicola A1 Shuwei Li A1 Nicolette Rodriguez A1 Patrick Reinecke A1 Rachid Karam A1 Virginia Speare A1 Mary Helen Black A1 Holly LaDuca A1 Xavier Llor YR 2019 UL http://jmg.bmj.com/content/56/12/838.abstract AB Background The clinical phenotype of CDH1 pathogenic variant carriers has mostly been studied in families that fulfil criteria of hereditary diffuse gastric cancer (HDGC). We aimed at determining cancer phenotype and cancer risk estimation among families with CDH1 pathogenic variants not selected by HDGC clinical criteria.Methods Patients were all consecutively identified CDH1 pathogenic variant carriers from a clinical laboratory tested with multigene panel testing and from an academic cancer genetics programme. Clinical and demographic features, cancer phenotypes and genotype–phenotype correlations were determined among CDH1 families. Age-specific cumulative cancer risks (penetrance) were calculated based on 38 families with available pedigrees.Results Within the 113 CDH1 pathogenic variant probands and 476 relatives, 113 had gastric cancer, 177 breast cancer and 196 other cancers. Mean age at diagnosis was 47 for gastric and 54 for breast cancer. Forty-six per cent fulfilled criteria of HDGC. While 36% of families had both gastric and breast cancers, 36% had breast but no gastric cancers and 16% had gastric but not breast cancers. Cumulative risk of cancer by age 80 was 37.2% for gastric and 42.9% for breast cancer.Conclusion In unselected CDH1 pathogenic variant carrier families, gastric cancer risks were lower and age at diagnosis higher than previously reported in families pre-selected for HDGC criteria. A substantial proportion of families did not present with any gastric cancers and their cancers were limited to breast. Thus, clinical criteria for CDH1 testing should be widened, including breast cancer families only, and a consideration for delayed prophylactic gastrectomy/surveillance should be evaluated.