PT - JOURNAL ARTICLE AU - Royston Ong AU - Denise Howting AU - Alethea Rea AU - Hayley Christian AU - Pauline Charman AU - Caron Molster AU - Gianina Ravenscroft AU - Nigel George Laing TI - Measuring the impact of genetic knowledge on intentions and attitudes of the community towards expanded preconception carrier screening AID - 10.1136/jmedgenet-2018-105362 DP - 2018 Nov 01 TA - Journal of Medical Genetics PG - 744--752 VI - 55 IP - 11 4099 - http://jmg.bmj.com/content/55/11/744.short 4100 - http://jmg.bmj.com/content/55/11/744.full SO - J Med Genet2018 Nov 01; 55 AB - Background Preconception carrier screening (PCS) provides the potential to empower couples to make reproductive choices before having an affected child. An important question is what factors influence the decision to use or not use PCS.Methods We analysed the relationship between knowledge, attitudes and intentions to participate in PCS using logistic regression in 832 participants in Western Australia.Results Two-thirds of participants said they would take the test, with 92% of these supporting screening for diseases reducing the lifespan of children and infants. Those who had good genetic knowledge were seven times more likely to intend to use PCS (p≤0.001), while those with high genetic knowledge were four times more likely to (p=0.002) and raised concerns such as insurance and confidentiality.Decreasing genetic knowledge correlated positively with religiosity and apprehension (p≤0.001), which correlated negatively with intention to use PCS (p≤0.001). Increasing genetic knowledge correlated positively with factors representing positive attitudes (p≤0.001), which correlated positively with intention to use PCS (p≤0.001). Many participants with good genetic knowledge nevertheless answered questions that tested understanding incorrectly.80% of participants stated they would prefer to access the test through their general practitioners and 30% would pay up to $A200.Conclusions Knowledge is instrumental in influencing participation. Having good genetic knowledge may not be enough to understand core concepts of PCS and may impact informed decision-making. This study recommends that continuous education of health professionals and thus the community, in PCS is crucial to reduce misconceptions.