PT - JOURNAL ARTICLE AU - Jeanna M McCuaig AU - Tracy L Stockley AU - Patricia Shaw AU - Michael Fung-Kee-Fung AU - Alon D Altman AU - James Bentley AU - Marcus Q Bernardini AU - Beatrice Cormier AU - Hal Hirte AU - Katharina Kieser AU - Andree MacMillan AU - Wendy S Meschino AU - Karen Panabaker AU - Renee Perrier AU - Diane Provencher AU - Kasmintan A Schrader AU - Kimberly Serfas AU - Eva Tomiak AU - Nora Wong AU - Sean S Young AU - Walter Henri Gotlieb AU - Paul Hoskins AU - Raymond H Kim ED - , TI - Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap AID - 10.1136/jmedgenet-2018-105472 DP - 2018 Sep 01 TA - Journal of Medical Genetics PG - 571--577 VI - 55 IP - 9 4099 - http://jmg.bmj.com/content/55/9/571.short 4100 - http://jmg.bmj.com/content/55/9/571.full SO - J Med Genet2018 Sep 01; 55 AB - The landscape of genetic testing in ovarian cancer patients has changed dramatically in recent years. The therapeutic benefits of poly ADP-ribose polymerase (PARP) inhibitors in treatment of BRCA1/2-related ovarian cancers has resulted in an increased demand and urgency for genetic testing results, while technological developments have led to widespread use of multi-gene cancer panels and development of tumour testing protocols. Traditional genetic counselling models are no longer sustainable and must evolve to match the rapid evolution of genetic testing technologies and developments in personalized medicine. Recently, representatives from oncology, clinical genetics, molecular genetics, pathology, and patient advocacy came together to create a national multi-disciplinary Canadian consortium. By aligning stakeholder interests, the BRCA Testing to Treatment (BRCA TtoT) Community of Practice aims to develop a national strategy for tumour and germline BRCA1/2 testing and genetic counselling in women with ovarian cancer. This article serves to provide an overview of the recent evolution of genetic assessment for BRCA1/2-associated gynecologic malignancies and outline a Canadian roadmap to facilitate change, improve genetic testing rates, and ultimately improve outcomes for hereditary ovarian cancer patients and their families.