PT - JOURNAL ARTICLE AU - Preeti Singh AU - Ranim Mahmoud AU - June-Anne Gold AU - Jennifer L Miller AU - Elizabeth Roof AU - Roy Tamura AU - Elisabeth ‎ Dykens AU - Merlin G Butler AU - Dan J Driscoll AU - Virginia Kimonis TI - Multicentre study of maternal and neonatal outcomes in individuals with Prader-Willi syndrome AID - 10.1136/jmedgenet-2017-105118 DP - 2018 May 18 TA - Journal of Medical Genetics PG - jmedgenet-2017-105118 4099 - http://jmg.bmj.com/content/early/2018/05/18/jmedgenet-2017-105118.short 4100 - http://jmg.bmj.com/content/early/2018/05/18/jmedgenet-2017-105118.full AB - Introduction Prader-Willi syndrome (PWS) is a complex genetic disorder associated with three different genetic subtypes: deletion of the paternal copy of 15q11-q13, maternal UPD for chromosome 15 and imprinting defect. Patients are typically diagnosed because of neonatal hypotonia, dysmorphism and feeding difficulties; however, data on the prenatal features of PWS are limited.Objective The aim of the study was to identify and compare frequencies of prenatal and neonatal clinical features of PWS among the three genetic subtypes.Methods Data from 355 patients with PWS from the Rare Diseases Clinical Research Network PWS registry were used to analyse multiple maternal and neonatal factors collected during an 8-year multisite study.Results Among our cohort of 355 patients with PWS (61% deletion, 36% UPD and 3% imprinting defect) 54% were born by caesarean section, 26% were born prematurely and 34% with a low birth weight (frequencies 32%, 9.6% and 8.1%, respectively, in the general population). Fetal movements were reported as decreased in 72%. All babies were hypotonic, and 99% had feeding difficulties. Low Apgar scores (<7) were noted in 17.7% and 5.6% of patients, respectively, compared with 1% and 1.4%, respectively, in the general population. Maternal age and pre-pregnancy weight were significantly higher in the UPD group (p=0.01 and <0.001, respectively).Conclusion We found a higher rate of perinatal complications in PWS syndrome compared with the general population. No significant differences in the genetic subtypes were noted except for a higher maternal age and pre-pregnancy weight in the UPD subgroup