RT Journal Article SR Electronic T1 Risk of breast cancer in male BRCA2 carriers JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 710 OP 711 DO 10.1136/jmg.2009.075176 VO 47 IS 10 A1 D G R Evans A1 I Susnerwala A1 J Dawson A1 E Woodward A1 E R Maher A1 F Lalloo YR 2010 UL http://jmg.bmj.com/content/47/10/710.abstract AB The risk of breast cancer for unaffected men who test positive for a BRCA2 mutation is based on very few retrospective studies. We have used both retrospective and prospective analysis in 321 families with pathogenic BRCA2 mutations. Three breast cancers occurred in male first-degree relatives after family ascertainment in 4140 years of follow-up suggesting a risk of breast cancer to 80 years of 8.9%. A second analysis excluding index cases identified 16 breast cancers in 905 first-degree male relatives on which Kaplan–Meier analysis was performed after assigning carrier status. This analysis confirmed that breast cancer risk in men was 7.1% (SE 5.2–8.6%) by age 70 years and 8.4% (SE 6.2–10.6%) by age 80 years.