PT  - JOURNAL ARTICLE
AU  - Y Yang
AU  - M Ma
AU  - L Li
AU  - W Zhang
AU  - C Xiao
AU  - S Li
AU  - Y Ma
AU  - D Tao
AU  - Y Liu
AU  - L Lin
AU  - S Zhang
TI  - Evidence for the association of Y-chromosome haplogroups with susceptibility to spermatogenic failure in a Chinese Han population
AID  - 10.1136/jmg.2007.054478
DP  - 2008 Apr 01
TA  - Journal of Medical Genetics
PG  - 210--215
VI  - 45
IP  - 4
4099  - http://jmg.bmj.com/content/45/4/210.short
4100  - http://jmg.bmj.com/content/45/4/210.full
SO  - J Med Genet2008 Apr 01; 45
AB  - Introduction: Y chromosomes are genetically highly variable due to frequent structural rearrangements. The variations may create a genetic background for the susceptibility to Y-related spermatogenic impairment, although few data have been accumulated about the possible correlation between the Y-chromosome haplotype and the predisposition of men to spermatogenic failure.Objective: To investigate the possible association of Y-chromosome background with spermatogenic failure.Methods: The distribution of 18 Y-chromosome haplogroups was compared between 414 infertile men with azoospermia or oligozoospermia and 262 normozoospermic men with or without AZFc deletions in a Han population of Southwest China.Results: A significant population difference in Y-haplogroup distribution was found between the groups of normozoospermia and azoospemia or oligozoospermia, and between the patient groups with oligozoospermia and azoospermia without AZFc deletions. Interpopulation comparison of Y haplogroup frequencies showed that the distribution of the haplogroups C, K* and O3* were significantly different between the groups.Conclusion: This study provides evidence for the association of Y-chromosome background with impaired spermatogenesis, suggesting that Y variations play a role in the occurrence and even the severity of spermatogenic failure. Furthermore, both AZFc deletions and other Y-chromosome structural variations may be important for determining the susceptibility to spermatogenic failure. Our findings emphasise the necessity of more extensive study on Y-chromosome variations for better understanding of spermatogenesis and its pathology.