RT Journal Article
SR Electronic
T1 A BRCA1 promoter variant (rs11655505) and breast cancer risk
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 268
OP 270
DO 10.1136/jmg.2009.073544
VO 47
IS 4
A1 Verderio, Paolo
A1 Pizzamiglio, Sara
A1 Southey, Melissa C
A1 Spurdle, Amanda B
A1 Hopper, John L
A1 Chen, Xiaoqing
A1 Beesley, Jonathan
A1 ,
A1 kConFab,
A1 Schmutzler, Rita K
A1 Engel, Christoph
A1 Burwinkel, Barbara
A1 Bugert, Peter
A1 Ficarazzi, Filomena
A1 Manoukian, Siranoush
A1 Barile, Monica
A1 Wappenschmidt, Barbara
A1 Chenevix-Trench, Georgia
A1 Radice, Paolo
A1 Peterlongo, Paolo
YR 2010
UL http://jmg.bmj.com/content/47/4/268.abstract
AB Background A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.–2265C→T) increases promoter activity and has a protective effect on breast cancer risk.Methods We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.Results No evidence for an association between rs11655505 and breast cancer risk was found.Conclusions Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.