TY - JOUR T1 - Germline mutation of microRNA-125a is associated with breast cancer JF - Journal of Medical Genetics JO - J Med Genet SP - 358 LP - 360 DO - 10.1136/jmg.2008.063123 VL - 46 IS - 5 AU - W Li AU - R Duan AU - F Kooy AU - S L Sherman AU - W Zhou AU - P Jin Y1 - 2009/05/01 UR - http://jmg.bmj.com/content/46/5/358.abstract N2 - MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer. ER -