PT  - JOURNAL ARTICLE
AU  - Li, W
AU  - Duan, R
AU  - Kooy, F
AU  - Sherman, S L
AU  - Zhou, W
AU  - Jin, P
TI  - Germline mutation of microRNA-125a is associated with breast cancer
AID  - 10.1136/jmg.2008.063123
DP  - 2009 May 01
TA  - Journal of Medical Genetics
PG  - 358--360
VI  - 46
IP  - 5
4099  - http://jmg.bmj.com/content/46/5/358.short
4100  - http://jmg.bmj.com/content/46/5/358.full
SO  - J Med Genet2009 May 01; 46
AB  - MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer.