RT Journal Article SR Electronic T1 Attenuated aerobic exercise capacity in CD36 deficiency JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 445 OP 447 DO 10.1136/jmg.2007.050070 VO 44 IS 7 A1 Hidekatsu Yanai A1 Ichiro Watanabe A1 Kojiro Ishii A1 Mie Morimoto A1 Hironobu Fujiwara A1 Shigeru Yoshida A1 Shu-Ping Hui A1 Kazuhiko Matsuno A1 Hitoshi Chiba YR 2007 UL http://jmg.bmj.com/content/44/7/445.abstract AB Background: An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency. Methods: We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (nā€Š=ā€Š22) and participants with CD36 deficiency (nā€Š=ā€Š12) during pedalling on a cycle ergometer. Results: In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate. Conclusion: This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.