%0 Journal Article %A K D Hadfield %A M J Smith %A D Trump %A W G Newman %A D G Evans %T SMARCB1 mutations are not a common cause of multiple meningiomas %D 2010 %R 10.1136/jmg.2009.075721 %J Journal of Medical Genetics %P 567-568 %V 47 %N 8 %X Background Schwannomas and meningiomas are both part of the tumour spectrum of neurofibromatosis type 2 (NF2) and are associated with somatic loss of chromosome 22. They are also found commonly within the general population, unrelated to NF2. Germline SMARCB1 mutations have recently been identified as a pathogenic cause of a subset of familial schwannomatosis cases, and SMARCB1 is a candidate gene for causation of both schwannomas and meningiomas. Recently, Bacci et al reported a germline SMARCB1 mutation associated with familial schwannomatosis and multiple meningiomas. They concluded that SMARCB1 mutations can predispose to multiple meningiomas.Methods We screened the SMARCB1 gene in a panel of 47 patients with multiple meningioma unrelated to NF2.Results We found no germline mutations.Conclusion We conclude that while meningiomas may be associated with the schwannomatosis phenotype, SMARCB1 is not a major contributor to multiple meningioma disease. %U https://jmg.bmj.com/content/jmedgenet/47/8/567.full.pdf