TY - JOUR T1 - <em>Heme oxygenase 1</em> variations and lung function decline in smokers: proof of replication JF - Journal of Medical Genetics JO - J Med Genet SP - 400 LP - 400 DO - 10.1136/jmg.2008.058123 VL - 45 IS - 6 AU - M Siedlinski AU - C C van Diemen AU - D S Postma AU - H M Boezen Y1 - 2008/06/01 UR - http://jmg.bmj.com/content/45/6/400.abstract N2 - We provide supportive evidence for a role of the promoter polymorphism (GT-repeat) in heme oxygenase 1 (HO-1) in relation to lung function loss over time. This observation has been made by Guénégou and colleagues in a Caucasian population, and a call for replication of these results in a larger and independent cohort was made.1 The relevance of HO-1 has been widely acknowledged.2 Chronic obstructive pulmonary disease (COPD)—often a consequence of abnormally accelerated lung function decline3—has been widely studied in relation to HO-1 promoter GT-repeat, using a … ER -