TY - JOUR T1 - Gene effects in environmentally determined subgroups JF - Journal of Medical Genetics JO - J Med Genet SP - 628 LP - 628 VL - 41 IS - 8 A2 - , Y1 - 2004/08/01 UR - http://jmg.bmj.com/content/41/8/628.abstract N2 - There has been controversy about the usefulness of stratification by environmentally determined subgroups in genetic research. In cancer epidemiology only a few genetic polymorphisms cause a substantial change in risk and many genes involved in the metabolism of mutagens have little or no effect. But the inclusion of environmental measures in genetic studies might reveal environment-gene interactions. Such combined studies have been questioned, however, on the grounds that they are unlikely to increase the power of the genetic study very much. … ER -