PT  - JOURNAL ARTICLE
AU  - R Huang
AU  - S E Poduslo
TI  - CYP19 haplotypes increase risk for Alzheimer’s disease
AID  - 10.1136/jmg.2005.039461
DP  - 2006 Aug 01
TA  - Journal of Medical Genetics
PG  - e42--e42
VI  - 43
IP  - 8
4099  - http://jmg.bmj.com/content/43/8/e42.short
4100  - http://jmg.bmj.com/content/43/8/e42.full
SO  - J Med Genet2006 Aug 01; 43
AB  - Cytochrome P450 aromatase, an enzyme that catalyses the conversion of androgens to oestrogen, is expressed at high levels in the gonads and in the brain. Aromatase activity is increased in the nucleus basalis of Meynert during aging and in Alzheimer’s disease (AD), making the gene (CYP19), at 15q21.1, a potential candidate risk factor.We examined 18 single nucleotide polymorphisms spanning the 5′-untranslated region and the entire coding region of CYP19 in 227 patients with AD and 131 control spouses.We found that the gene region could be divided into two haplotype blocks; a haplotype in block 1 and a haplotype in block 2 increased the risk of developing the disease by twofold in APOE 4 carriers. The implication of two haplotypes conferring increased risk for AD warrants further investigation of the regulation of aromatase activity in brain.