RT Journal Article SR Electronic T1 Multiple meningiomas: differential involvement of the NF2 gene in children and adults JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 45 OP 48 DO 10.1136/jmg.2004.023705 VO 42 IS 1 A1 Evans, D G R A1 Watson, C A1 King, A A1 Wallace, A J A1 Baser, M E YR 2005 UL http://jmg.bmj.com/content/42/1/45.abstract AB Objective: To screen for NF2 mutations in people with meningiomas. Methods: Lymphocyte or tumour DNA was analysed from 46 individuals from 36 families who presented with a meningioma at age ⩽15 years without vestibular schwannoma (VS), or who had multiple meningiomas in adulthood before the diagnosis of VS. Results: Eight of 13 people with meningioma and other features of neurofibromatosis 2 (NF2) had an identified constitutional NF2 mutation in blood DNA, but none of the other subjects had identified constitutional NF2 mutations. Conclusions: Constitutional NF2 mutations are the most likely cause of meningioma in children and in people with a meningioma plus other non-VS features of NF2. Mosaic NF2 may be the cause of about 8% of multiple meningiomas in sporadic adult cases, but there are other causes in the majority of other such patients and in multiple meningioma in families.