TY - JOUR T1 - Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes JF - Journal of Medical Genetics JO - J Med Genet SP - 563 LP - 567 DO - 10.1136/jmg.2005.035345 VL - 43 IS - 7 AU - M L Hamshere AU - N M Williams AU - N Norton AU - H Williams AU - A G Cardno AU - S Zammit AU - L A Jones AU - K C Murphy AU - R D Sanders AU - G McCarthy AU - M Y Gray AU - G Jones AU - P Holmans AU - M C O’Donovan AU - M J Owen AU - N Craddock Y1 - 2006/07/01 UR - http://jmg.bmj.com/content/43/7/563.abstract N2 - Background: Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression. Methods: We undertook analyses in an attempt to detect loci that influence susceptibility to, or modify the clinical expression of, schizophrenia according to the occurrence of episodes of major depression. We used a logistic regression framework in which lifetime presence/absence of major depression was entered as a covariate in the linkage analysis of our UK schizophrenia affected sibling pair series (168 affected sibling pairs typed for a 10 cM map of microsatellite markers). Results: Inclusion of presence/absence of depression as a covariate detected a genome wide significant linkage signal on chromosome 4q28.3 at 130.7 cM (LOD = 4.59; p = 0.038; increase in maximum LOD over univariate analysis (ILOD) = 3.62). Inclusion of the depression covariate also showed suggestive evidence of linkage on 20q11.21 (LOD = 4.10; expected to occur by chance 0.093 times per genome scan, ILOD = 2.83). Conclusions: Our findings identify loci that may harbour genes that play a role in susceptibility to, or modify the risk of, episodes of major depression in people with schizophrenia. ER -