RT Journal Article
SR Electronic
T1 The <em>IRF5</em> polymorphism in type 1 diabetes
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 670
OP 672
DO 10.1136/jmg.2007.050971
VO 44
IS 10
A1 Qu, Hui-Qi
A1 Marchand, Luc
A1 Grabs, Rosemary
A1 Polychronakos, Constantin
YR 2007
UL http://jmg.bmj.com/content/44/10/670.abstract
AB The interferon regulatory factor 5 gene (IRF5) has been shown to play a crucial role in harmful immune responses by induction of proinflammatory cytokines. Functional genetic variants associated with increasd IRF5 expression of specific isoforms are associated with systemic lupus erythematosus (SLE) and it is possible that they may also predispose to other autoimmune disorders. We tested the association of two IRF5 SNPs, correlated with IRF5 expression and SLE risk, in 947 nuclear family trios type 1 diabetes (T1D) using the transmission disequilibrium test. Our results suggest that the functional IRF5 variations do not confer an obvious risk for T1D.