PT  - JOURNAL ARTICLE
AU  - Hui-Qi Qu
AU  - Luc Marchand
AU  - Rosemary Grabs
AU  - Constantin Polychronakos
TI  - The <em>IRF5</em> polymorphism in type 1 diabetes
AID  - 10.1136/jmg.2007.050971
DP  - 2007 Oct 01
TA  - Journal of Medical Genetics
PG  - 670--672
VI  - 44
IP  - 10
4099  - http://jmg.bmj.com/content/44/10/670.short
4100  - http://jmg.bmj.com/content/44/10/670.full
SO  - J Med Genet2007 Oct 01; 44
AB  - The interferon regulatory factor 5 gene (IRF5) has been shown to play a crucial role in harmful immune responses by induction of proinflammatory cytokines. Functional genetic variants associated with increasd IRF5 expression of specific isoforms are associated with systemic lupus erythematosus (SLE) and it is possible that they may also predispose to other autoimmune disorders. We tested the association of two IRF5 SNPs, correlated with IRF5 expression and SLE risk, in 947 nuclear family trios type 1 diabetes (T1D) using the transmission disequilibrium test. Our results suggest that the functional IRF5 variations do not confer an obvious risk for T1D.