RT Journal Article SR Electronic T1 The HNPCC associated MSH2*1906G→C founder mutation probably originated between 1440 CE and 1715 CE in the Ashkenazi Jewish population JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 766 OP 768 DO 10.1136/jmg.2005.030999 VO 42 IS 10 A1 S Sun A1 C M T Greenwood A1 I Thiffault A1 N Hamel A1 G Chong A1 W D Foulkes YR 2005 UL http://jmg.bmj.com/content/42/10/766.abstract AB The MSH2*1906G→C mutation was recently shown to be a rare yet highly penetrant mutation leading to colorectal cancer. The mutation was only found among Ashkenazi Jewish individuals and lies on an extended haplotype that is common in that population. This study determined that the mutation probably arose between 11 and 22 generations ago, during the time when the Ashkenazim were living in eastern Europe.