PT  - JOURNAL ARTICLE
AU  - S Sun
AU  - C M T Greenwood
AU  - I Thiffault
AU  - N Hamel
AU  - G Chong
AU  - W D Foulkes
TI  - The HNPCC associated <em>MSH2*1906G→C</em> founder mutation probably originated between 1440 CE and 1715 CE in the Ashkenazi Jewish population
AID  - 10.1136/jmg.2005.030999
DP  - 2005 Oct 01
TA  - Journal of Medical Genetics
PG  - 766--768
VI  - 42
IP  - 10
4099  - http://jmg.bmj.com/content/42/10/766.short
4100  - http://jmg.bmj.com/content/42/10/766.full
SO  - J Med Genet2005 Oct 01; 42
AB  - The MSH2*1906G→C mutation was recently shown to be a rare yet highly penetrant mutation leading to colorectal cancer. The mutation was only found among Ashkenazi Jewish individuals and lies on an extended haplotype that is common in that population. This study determined that the mutation probably arose between 11 and 22 generations ago, during the time when the Ashkenazim were living in eastern Europe.