PT - JOURNAL ARTICLE AU - M M de Jong AU - I M Nolte AU - G J te Meerman AU - W T A van der Graaf AU - J C Oosterwijk AU - J H Kleibeuker AU - M Schaapveld AU - E G E de Vries TI - Genes other than <em>BRCA1</em> and <em>BRCA2</em> involved in breast cancer susceptibility AID - 10.1136/jmg.39.4.225 DP - 2002 Apr 01 TA - Journal of Medical Genetics PG - 225--242 VI - 39 IP - 4 4099 - http://jmg.bmj.com/content/39/4/225.short 4100 - http://jmg.bmj.com/content/39/4/225.full SO - J Med Genet2002 Apr 01; 39 AB - This review focuses on genes other than the high penetrance genes BRCA1 and BRCA2 that are involved in breast cancer susceptibility. The goal of this review is the discovery of polymorphisms that are either associated with breast cancer or that are in strong linkage disequilibrium with breast cancer causing variants. An association with breast cancer at a 5% significance level was found for 13 polymorphisms in 10 genes described in more than one breast cancer study. Our data will help focus on the further analysis of genetic polymorphisms in populations of appropriate size, and especially on the combinations of such polymorphisms. This will facilitate determination of population attributable risks, understanding of gene-gene interactions, and improving estimates of genetic cancer risks.