TY - JOUR T1 - Array painting: a method for the rapid analysis of aberrant chromosomes using DNA microarrays JF - Journal of Medical Genetics JO - J Med Genet SP - 664 LP - 670 DO - 10.1136/jmg.40.9.664 VL - 40 IS - 9 AU - H Fiegler AU - S M Gribble AU - D C Burford AU - P Carr AU - E Prigmore AU - K M Porter AU - S Clegg AU - J A Crolla AU - N R Dennis AU - P Jacobs AU - N P Carter Y1 - 2003/09/01 UR - http://jmg.bmj.com/content/40/9/664.abstract N2 - Objective: The authors describe a method, termed array painting, which allows the rapid, high resolution analysis of the content and breakpoints of aberrant chromosomes. Methods: Array painting is similar in concept to reverse chromosome painting and involves the hybridisation of probes generated by PCR of small numbers of flow sorted chromosomes on large insert genomic clone DNA microarrays. Results and Conclusions: By analysing patients with cytogenetically balanced chromosome rearrangements, the authors show the effectiveness of array painting as a method to map breakpoints prior to cloning and sequencing chromosome rearrangements. ER -