RT Journal Article
SR Electronic
T1 Transient neonatal diabetes, a disorder of imprinting
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 872
OP 875
DO 10.1136/jmg.39.12.872
VO 39
IS 12
A1 I K Temple
A1 J P H Shield
YR 2002
UL http://jmg.bmj.com/content/39/12/872.abstract
AB Transient neonatal diabetes (TND) is a rare but distinct type of diabetes. Classically, neonates present with growth retardation and diabetes in the first week of life. Apparent remission occurs by 3 months but there is a tendency for children to develop diabetes in later life. Evidence suggests it is the result of overexpression of an imprinted and paternally expressed gene/s within the TND critical region at 6q24. Two imprinted genes, ZAC (zinc finger protein associated with apoptosis and cell cycle arrest) and HYMAI (imprinted in hydatidiform mole) have been identified as potential candidates. Three genetic mechanisms have been shown to result in TND, paternal uniparental isodisomy of chromosome 6, paternally inherited duplication of 6q24, and a methylation defect at a CpG island overlapping exon 1 of ZAC/HYMAI.