RT Journal Article
SR Electronic
T1 Acromicric dysplasia: long term outcome and evidence of autosomal dominant inheritance
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 745
OP 749
DO 10.1136/jmg.38.11.745
VO 38
IS 11
A1 Faivre, L
A1 Le Merrer, M
A1 Baumann, C
A1 Polak, M
A1 Chatelain, P
A1 Sulmont, V
A1 Cousin, J
A1 Bost, M
A1 Cordier, M P
A1 Zackai, E
A1 Russell, K
A1 Finidori, G
A1 Pouliquen, J C
A1 Munnich, A
A1 Maroteaux, P
A1 Cormier-Daire, V
YR 2001
UL http://jmg.bmj.com/content/38/11/745.abstract
AB Acromicric dysplasia is a rare bone dysplasia characterised by short stature, short hands and feet, normal intelligence, mild facial dysmorphism, and characteristic x ray abnormalities of the hands. Only a very small number of children with this condition have been reported so far. Here we report on a series of 22 patients including 10 boys and 12 girls with acromicric dysplasia. Length was normal at birth and height fell progressively off the centiles postnatally. The mean adult height was 130 cm (133 cm in males, 129 cm in females). The hands, feet, and limbs were short and OFC was normal. Intelligence was normal and mild dysmorphic features were noted. Other occasional features included well developed muscles, a hoarse voice, generalised joint limitation in some patients, frequent ear, tracheal, and respiratory complication, and spine abnormalities. Long term follow up showed that facial dysmorphism was less obvious in adults and that carpal tunnel syndrome was frequent in older patients. Apart from short metacarpals and phalanges, internal notch of the second metacarpal, external notch of the fifth metacarpal, and internal notch of the femoral heads, there were no majorx ray abnormalities. No major complications, such as cardiac disease or major orthopaedic problems, occurred in the course of the disease. The condition appeared to be sporadic in 16 cases but the observation of vertical transmission in three families was consistent with an autosomal dominant mode of inheritance.